IMA/MOTUS - Vials Filling Line

IMA/MOTUS HOF VIALS FILLING LINE

Pharmaceutical production equipment for the manufacturing and processing of pantoprazole in vials. The line is composed of formulation systems, vial cleaning, depyrogenation, filling, freeze-drying, and crimp-capping machines. The photographs show the equipment in its existing production environment.

The setup is complemented by autoclaves, cleaning equipment, an H₂O₂ decontamination airlock with a generator, weighing and air-handling systems, and equipment for the optical inspection of vials.

• Preparation of the formulation in three 200-liter vessels
• Cleaning of vials, followed by depyrogenation, and filling of vials
• Tray handling, followed by loading of the freeze-dryers
• Freeze-drying using the three HOF units
• Crimping (sealing) and optical inspection
• Cleaning and sterilization of production components
• The combination of vial washing, depyrogenation, filling, and freeze-drying represents an established process sequence for pharmaceutical vial lines.

The central process line integrates equipment from IMA, HOF Specialized Equipment Manufacturing, and Motus.

For formulation, three 200-liter mixing vessels from Gross Tank Construction are provided. Vials are cleaned using an IMA Hydra 1500 and subsequently fed into an IMA Blue Galaxy 1250 depyrogenation tunnel.

Further processing is carried out via an IMA F2000 filling machine, an IMA V600 tray loader, and a Motus/HOF loading and unloading system. The equipment inventory includes three HOF freeze-dryers as well as an IMA ALU 600 crimp-capping machine (visible in the photographs).

PRODUCTION CHARACTERISTICS

• Primary container: Vials
• Compounding/mixing vessels: 3 × 200 liters
• Freeze dryers (lyophilizers): 3 units
• Semi-automatic inspection machines: 4 units
• Total inventory: 56 line items, some comprising multiple individual pieces of equipment